… blockers and thereby reduce renal side effects. This report describes the design and synthesis
of novel ENaC blockers that … We found that all of the compounds synthesized in this study …

… , chronic obstructive pulmonary disease (COPD) and chronic … further conclusions regarding
structure–activity relationships; … -02), a novel epithelial sodium channel blocker with potential …

… successful in blocking ENaC activity, and in many cases, novel ENaC blockers are amiloride
… Years of optimizing amiloride structure–activity relationships have taught us that first, a …

… In summary, compound 552-02 is a novel potent, more selective, less epithelial-permeant,
more durable epithelial sodium channel blocker than amiloride. When administered as an …

… Thus, our novel optical tool can be operated by turning on and … ENaC blocker PA1 has
been designed, synthesized and … new insights into the structure–activity relationships of the …

… epithelial sodium channel … chronic bronchitis exacerbations and other syndromes associated
with reductions in mucociliary clearance, thereby creating the possibility for novel treatment …

… produces a phenotype similar to cystic fibrosis (CF) with airway … Structure-activity analyses
of the inhibitory peptide revealed … and chronic bronchitis (10). Amiloride is a prototypic ENaC …

… In clinical trials, amiloride (an epithelial sodium channel blocker with … Design, synthesis,
and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium …

… The discovery and development of novel ENaC inhibitors are thus still an important area of
… Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-…

… epithelial sodium channel that regulates salt and water reabsorption in epithelia, causes
several human diseases, including cystic … As most of these hit genes are novel proteins for …